2. Inhibitory Antibodies
  3. Ociperlimab

Ociperlimab  (Synonyms: 欧司珀利单抗; BGB-A1217)

目录号: HY-P99763 纯度: 98.14%
COA

摩尔计算器

Ociperlimab 是一种人源化 IgG1 抗 TIGIT 抗体。Ociperlimab 以高亲和力结合人 TIGIT 的细胞外结构域 (KD = 0.135 nM)。Ociperlimab 阻断 TIGIT 与其配体 PVR 或 PVR-L2 之间的相互作用。Ociperlimab 可用于癌症研究。

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CAS No. : 2342597-93-5

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规格 价格 是否有货 数量
1 mg ￥3500
In-stock
5 mg ￥9100
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Ociperlimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ociperlimab is a humanized IgG1 anti-TIGIT antibody. Ociperlimab binds to the extracellular domain of human TIGIT with high affinity (KD = 0.135 nM). Ociperlimab blocks the interaction between TIGIT and its ligands PVR or PVR-L2. Ociperlimab can be used in research of cancer[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
体外研究
(In Vitro)

Ociperlimab (BGB-A1217; 0-10 μg/mL) 增强增强巨细胞病毒特异性 T 细胞分泌的 IFN-γ[1]。
Ociperlimab (1-1000 ng/mL) 以 Fc 依赖性方式激活自然杀伤细胞和单核细胞[1]。
Ociperlimab 在体外通过 Fc 依赖性内吞作用从 T 细胞表面去除 TIGIT[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ociperlimab 相关抗体:
体内研究
(In Vivo)

Ociperlimab (BGB-A1217; 3 和 10 mg/kg; 腹腔注射; CT26 WT 荷瘤人源化 TIGIT 敲入小鼠和 MC38 荷瘤人源化 TIGIT 敲入小鼠) 以 Fc 依赖性方式产生抗肿瘤功效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT26 WT tumor-bearing humanized TIGIT knock-in mice and MC38 tumor-bearing humanized TIGIT knock-in mice[1]
Dosage: 3 and 10 mg/kg
Administration: Intraperitoneal injection
Result: Inhibited tumor growth compared to the single agent treatment groups.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

欧司珀利单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized TIGIT Protein, Human can bind Ociperlimab. The EC50 for this effect is 20.39 ng/mL.
纯度 & 产品资料

纯度: 98.14%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Ociperlimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ociperlimab2342597-93-5BGB-A1217欧司珀利单抗OthersPVRPVR-L2CMV-specific T cellscancerFcInhibitorinhibitorinhibit

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